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Table 7 Blood–brain permeability-surface area products (PS) from influx data and calculated blood–brain barrier efflux rate constants, keff,BBB for mannitol, sucrose and inulin

From: Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier

  PS/(10−2 µL g−1 min−1) keff,BBB/min−1
Mannitol
 Ohno et al. [591] 180 0.0090
 Amtorp [592] 121 0.0061
 Preston et al. [593] 72 0.0036
 Sisson and Oldendorf [594] 10 0.0005
 Daniel et al. [595] 49 0.0025
 Preston and Haas [531] as purchaseda, c 68 0.0034
 Purifiedc 44 0.0022
 Average   0.0040
 s.e.m   0.0013
Sucrose
 Ohno et al. [591] 40 0.002
 Amtorp [592] 20 0.001
 Preston et al. [593] 48 0.0024
 Davson and Spaziani # [596] 22 0.0011
 Reed and Woodbury [597] 5.3 0.00026
 Cameron et al. # [598] 33 0.0017
 Preston and Haas [531] as purchaseda, c 37 0.0019
 Purifiedc 15.3 0.00076
 Smith [599] 24 0.0012
 Preston and Webster 2002 [600] 11.8 0.00059
 Miah et al. [532] radiolabelleda 40 0.002
 Miah et al. [532] mass spec. 4 0.0002
 Average   0.0011
 s.e.m   0.0002
Inulin
 Ohno et al. [591] 1.44–2 0.00008
 Amtorp [592] 15 0.00075
 Preston et al. [593] 9 0.00045
 Reed and Woodbury [597] < ~ 0.3 0.00002
 Daniel et al. [595] 6 0.0003
 Smith [599] < 1.5 0.00006
 Preston and Webster [600] 3.9 0.0002
 Kakee et al. [601]b 30 0.0015
 Average   0.00027
 s.e.m   0.00010
  1. The volume of distribution is assumed to be 0.2 mL g−1. Italic values are excluded from calculations because athey are for comparison with the accompanying values or bit is an outlier, more than 4 st. dev. from the mean of the other values for inulin. The values for mannitol and sucrose marked care reported for the radiolabelled substances both as purchased and following purification to remove impurities which might be transported more rapidly (see text). The average for sucrose is significantly different from than that for mannitol, p = 0.012, and that for inulin different from that for sucrose, p = 0.01. Data obtained with rats (except # in rabbits)