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Table 3 Amino acid concentrations in plasma, CSF and ISF

From: Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier

  Plasma concentration/µM CSF concentration/µM ISF concentration/µM
Human1 Rat2 Human3 Rabbit4 Rat5 Mice6 Human1 Human7 Rat2, c Rat1, 2 Human3 Rabbit4 Rat5 Mice6 Rabbit4 Rabbit8 Rabbit9 Rat5 Mice6
Gln   619 641 868 834 598    863 780 552 583 524 517 250 547 159 193 80
Asn    112 55    Trace     14 16    3 7.8 4.3   1.4
Ala 330   489a 382 430 408 27 18.6    34a 39 85.4 57 15 19 15 7.7 9.3
Ser 149 196 140 263 247 109 28.9 30.4 79 80 30 116 62.3 37 34    24.9 9.8
Gly 249 221 283    246 1.3 6.4 20 15 6    34      7.8
Pro 212      60 Trace 0.6       4.2      1.8
Thr 142   166    113 28.5 27.7    36    22      3.5
Val 222 430 309 191   173 14 16.1 78 47 20 14   9.4 13 12.5 7.4   2.9
Leu 109 432 155 81   127 13.1 11.9 66 42 15 7   6.6 9     1.5
Ile 61   77 101    5.2 4.7    6 7    9     
Tyr 70   73 43   54 7.3 8.1    10 7   7.2 5     0.7
His 85   80    59 10.8 12.0    12    8.9      1.2
Lys 158 290 171 137   321 19.7 22.0 120 87 21 8   46 19     10
Arg 80 94 81   227 103 17 18.6 55 46 22   32.5 18     6.9 3.2
Glu 83   61 56 159.6 37 7.2 8.7    26 10 11.4 21 4 4.3 3.4 2.9 4.1
Asp 7     33.8   2.4 1.5      5.8    0.6 0.5 1.7  
Phe 71   64 45    8.3 8.2    10 7    6     
Met 41   28 30    2.8 2.6    3     3     
Trp 62                   
  1. Concentrations measured in CSF are, with the exception of glutamine always substantially less, than the concentrations in plasma. Concentrations in ISF are measured by microdialysis with extrapolation to zero flow (see text). If these are correct, ISF concentrations are substantially lower than those in CSF. c cisternal, l lumbar
  2. 1Plum et al. [576]
  3. 2Franklin et al. [577]
  4. 3McGale et al. [578]
  5. 4Hamberger et al. [579]
  6. 5Lerma et al. [580]
  7. 6Dolgodilina et al. [581]
  8. 7Table 8.15 in Davson and Segal [56]
  9. 8Jacobson et al. [582] microdialysis by concentration profile
  10. 9Jacobson et al. [582] microdialysis by recovery of samples