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Fig. 24 | Fluids and Barriers of the CNS

Fig. 24

From: Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier

Fig. 24

(Figure reproduced from [4])

Diagram illustrating possible schemes for neurovascular coupling, i.e. regulation of blood flow changes associated with nerve activity. Two forms of control are shown, a simple feedback based on the signal to be regulated, e.g. pCO2, and b feedback plus feed-forward. The feed-forward element, signal2, in b, possibly from astrocytes, allows blood flow to increase with smaller changes in the primary quantity to be regulated, signal1

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