Fig. 7From: Sex-specific differences in organic anion transporting polypeptide 1a4 (Oatp1a4) functional expression at the blood–brain barrier in Sprague–Dawley ratsBrain uptake of the Oatp transport substrate taurocholate in castrated male and ovariectomized female Sprague–Dawley rats. Uptake of [3H]taurocholate was measured via an in situ brain perfusion study. Animals were perfused with [3H]taurocholate (1.0 μCi/ml) for 10 min. a Castration resulted in an increase in taurocholate uptake in castrated males compared to sham operated control males. b Ovariectomy of female rats did not result in significant changes in taurocholate uptake as compared to sham operated female to sham operated female rats. Results are expressed as mean ± SD from six animals per treatment group. **p < 0.01Back to article page