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Fig. 7 | Fluids and Barriers of the CNS

Fig. 7

From: Sex-specific differences in organic anion transporting polypeptide 1a4 (Oatp1a4) functional expression at the blood–brain barrier in Sprague–Dawley rats

Fig. 7

Brain uptake of the Oatp transport substrate taurocholate in castrated male and ovariectomized female Sprague–Dawley rats. Uptake of [3H]taurocholate was measured via an in situ brain perfusion study. Animals were perfused with [3H]taurocholate (1.0 μCi/ml) for 10 min. a Castration resulted in an increase in taurocholate uptake in castrated males compared to sham operated control males. b Ovariectomy of female rats did not result in significant changes in taurocholate uptake as compared to sham operated female to sham operated female rats. Results are expressed as mean ± SD from six animals per treatment group. **p < 0.01

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