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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Sex-specific differences in organic anion transporting polypeptide 1a4 (Oatp1a4) functional expression at the blood–brain barrier in Sprague–Dawley rats

Fig. 2

Expression of Slco1a4 mRNA and Oatp1a4 protein in brain microvessels isolated from male and female Sprague–Dawley rats. a Slco1a4 mRNA is increased in microvessels isolated from female Sprague–Dawley rats as compared to age-matched males. Results are expressed as mean ± SD of three experiments with each group consisting of mRNA samples from six individual experimental animals, **p < 0.01. b Western blot showed a single Oatp1a4 band at 90 kDa and a single band associated with tubulin at 50 kDa. While tubulin expression is the same between sexes, females (F1–6) show an approximately 3.5-fold higher expression of Oatp1a4 as compared to male animals (M1–6). Results are expressed as mean ± SD of the ratio of Oatp1a4 protein expression to tubulin protein expression from six animals per treatment group. MWM molecular weight marker. *p < 0.05

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