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Table 1 Effect of Na+- or Cl-replacement, and co-presence of compounds on [3H]p-TA uptake by isolated rat choroid plexus

From: Role of cationic drug-sensitive transport systems at the blood-cerebrospinal fluid barrier in para-tyramine elimination from rat brain

Compounds Concentration (mM) Percentage of control
Na + /Cl -replacement
 Control   100 ± 5
 Na+-free   93.6 ± 3.9
 Cl-free   98.4 ± 5.8
Co-presence of compounds
 Control   100 ± 9
 p-TA 10 65.9 ± 4.6**
 Propranolol 10 61.0 ± 5.4**
 Pyrilamine 10 61.2 ± 0.8**
 Amantadine 10 61.4 ± 0.6**
 Imipramine 1 67.4 ± 1.1*
 Verapamil 1 70.8 ± 1.1*
 Choline 10 72.3 ± 4.6*
 Serotonin 10 79.6 ± 2.2
 MPP+ 10 84.7 ± 6.3
 TEA 10 93.0 ± 3.1
 PAH 10 95.4 ± 5.1
  1. [3H]p-TA uptake by isolated rat choroid plexus (1 µCi/sample) was performed at 37 °C for 45 s in the absence (control) or presence of Na+ and Cl without (control) or with unlabeled compounds. Each value represents the mean ± S.E.M. (n = 3–8)
  2. MPP + 1-methyl-4-phenylpyridinium, PAH p-aminohippurate, TEA tetraethylammonium, p-TA para-tyramine
  3. *p < 0.05 and **p < 0.01, significantly different from control