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Table 1 Effect of Na+- or Cl−-replacement, and co-presence of compounds on [3H]p-TA uptake by isolated rat choroid plexus

From: Role of cationic drug-sensitive transport systems at the blood-cerebrospinal fluid barrier in para-tyramine elimination from rat brain

Compounds

Concentration (mM)

Percentage of control

Na + /Cl −-replacement

 Control

 

100 ± 5

 Na+-free

 

93.6 ± 3.9

 Cl−-free

 

98.4 ± 5.8

Co-presence of compounds

 Control

 

100 ± 9

 p-TA

10

65.9 ± 4.6**

 Propranolol

10

61.0 ± 5.4**

 Pyrilamine

10

61.2 ± 0.8**

 Amantadine

10

61.4 ± 0.6**

 Imipramine

1

67.4 ± 1.1*

 Verapamil

1

70.8 ± 1.1*

 Choline

10

72.3 ± 4.6*

 Serotonin

10

79.6 ± 2.2

 MPP+

10

84.7 ± 6.3

 TEA

10

93.0 ± 3.1

 PAH

10

95.4 ± 5.1

  1. [3H]p-TA uptake by isolated rat choroid plexus (1 µCi/sample) was performed at 37 °C for 45 s in the absence (control) or presence of Na+ and Cl− without (control) or with unlabeled compounds. Each value represents the mean ± S.E.M. (n = 3–8)
  2. MPP + 1-methyl-4-phenylpyridinium, PAH p-aminohippurate, TEA tetraethylammonium, p-TA para-tyramine
  3. *p < 0.05 and **p < 0.01, significantly different from control
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Fluids and Barriers of the CNS

ISSN: 2045-8118