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Table 2 Comparison of cerebrospinal fluid absolute and normalized concentrations of common cytokines in control and post-hemorrhagic hydrocephalus subjects

From: Chemokine and cytokine levels in the lumbar cerebrospinal fluid of preterm infants with post-hemorrhagic hydrocephalus

  Control mean (SD) PHH mean (SD) Mean difference 95% confidence interval p value
Total protein (μg/ml) 1540 (985.6) 3285 (2265.9) 1745.0 2714–775.3 0.0008
IL-1α (pg/ml) 2.385 (3.758) 13.51 (11.03) 11.13 17.67–4.577 0.0019
Normalized IL- 1.58E−7 (2.72E−7) 4.89E−7 (4.56E−7) 3.31E−7 6.40E−7 to 2.31E−8 0.0363
IL-1β (pg/ml) 4.600 (15.05) 79.89 (146.3) 75.29 156.2 to − 5.664 n.s.
Normalized IL- 1.27E−7 (2.93E−7) 1.90E−6 (2.2E−6) 1.78E−6 3.02E−6 to 5.31E−7 0.0072
IL-4 (pg/ml) 0.266 (0.4465) 1.010 (0.5653) 0.7444 − 1.173 to − 0.3164 0.0016
Normalized IL-4 1.64E−9 (2.53E−9) 4.20E-9 (3.55E−9) 2.56E−9 5.13E−9 to − 1.11E−11 n.s.
IL-6 (pg/ml) 268.2 (667.8) 981.3 (932.6) 713.1 1389–37.32 0.0395
Normalized IL-6 1.8E−5 (5.6E−5) 4.27E−5 (5.82E−5) 2.49E−5 7.38E−5 to − 2.40E−5 n.s.
IL-8 (pg/ml) 522.5 (528) 1958 (3158) 1436 3205 to − 333.3 n.s.
Normalized IL-8 4.4E−5 (5.3E−5) 1.04E−4 (1.95E−4) 6.0E−5 1.9E−4 to − 6.7E−5 n.s.
IL-10 (pg/ml) 5.154 (14.59) 128 (274.8) 122.8 274.1 to − 28.38 n.s.
Normalized IL-10 1.81E−7 (3.13E−7) 2.53E−6 (3.75E−6) 2.35E−6 4.42E−6 to 2.84E−7 0.0277
IL-12 (pg/ml) 1.763 (2.446) 11.58 (9.234) 9.819 15.14 to 4.497 0.0009
Normalized IL-12 1.3E−7 (2.2E−7) 3.75E−7 (3.12E−7) 2.45E−7 4.70E−7 to 2.043E−8 0.0339
TNF-α (pg/ml) 2.147 (3.337) 9.71 (7.384) 7.566 12.18–2.951 0.0026
Normalized TNF-α 1.61E−7 (3.0E−7) 3.42E−7 (2.97E−7) 1.81E−7 4.38E−7 to − 7.55E−8 n.s.
TGF-β1 (ng/ml) 0.4504 (0.8607) 1.161 (2.270) 0.7103 2.278 to − 0.857 n.s.
Normalized TGF-β1 1.9E−5 (2.0E−5) 2.4E−5 (2.1E−5) 4.55E−6 2.02E−5 to − 1.5E−5 n.s.
IFN-γ (pg/ml) 0.6463 (1.552) 1.191 (1.357) 0.5446 1.812 to − 0.7226 n.s.
Normalized IFN-γ 2.93E−8 (5.65E−8) 3.42E−8 (2.35E−8) 4.91E−9 4.44E−8 to − 3.45E−8 n.s.
  1. SD standard deviation, PHH: post-hemorrhagic hydrocephalus