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Table 2 Comparison of cerebrospinal fluid absolute and normalized concentrations of common cytokines in control and post-hemorrhagic hydrocephalus subjects

From: Chemokine and cytokine levels in the lumbar cerebrospinal fluid of preterm infants with post-hemorrhagic hydrocephalus

 

Control mean (SD)

PHH mean (SD)

Mean difference

95% confidence interval

p value

Total protein (μg/ml)

1540 (985.6)

3285 (2265.9)

1745.0

2714–775.3

0.0008

IL-1α (pg/ml)

2.385 (3.758)

13.51 (11.03)

11.13

17.67–4.577

0.0019

Normalized IL-1α

1.58E−7 (2.72E−7)

4.89E−7 (4.56E−7)

3.31E−7

6.40E−7 to 2.31E−8

0.0363

IL-1β (pg/ml)

4.600 (15.05)

79.89 (146.3)

75.29

156.2 to − 5.664

n.s.

Normalized IL-1β

1.27E−7 (2.93E−7)

1.90E−6 (2.2E−6)

1.78E−6

3.02E−6 to 5.31E−7

0.0072

IL-4 (pg/ml)

0.266 (0.4465)

1.010 (0.5653)

0.7444

− 1.173 to − 0.3164

0.0016

Normalized IL-4

1.64E−9 (2.53E−9)

4.20E-9 (3.55E−9)

2.56E−9

5.13E−9 to − 1.11E−11

n.s.

IL-6 (pg/ml)

268.2 (667.8)

981.3 (932.6)

713.1

1389–37.32

0.0395

Normalized IL-6

1.8E−5 (5.6E−5)

4.27E−5 (5.82E−5)

2.49E−5

7.38E−5 to − 2.40E−5

n.s.

IL-8 (pg/ml)

522.5 (528)

1958 (3158)

1436

3205 to − 333.3

n.s.

Normalized IL-8

4.4E−5 (5.3E−5)

1.04E−4 (1.95E−4)

6.0E−5

1.9E−4 to − 6.7E−5

n.s.

IL-10 (pg/ml)

5.154 (14.59)

128 (274.8)

122.8

274.1 to − 28.38

n.s.

Normalized IL-10

1.81E−7 (3.13E−7)

2.53E−6 (3.75E−6)

2.35E−6

4.42E−6 to 2.84E−7

0.0277

IL-12 (pg/ml)

1.763 (2.446)

11.58 (9.234)

9.819

15.14 to 4.497

0.0009

Normalized IL-12

1.3E−7 (2.2E−7)

3.75E−7 (3.12E−7)

2.45E−7

4.70E−7 to 2.043E−8

0.0339

TNF-α (pg/ml)

2.147 (3.337)

9.71 (7.384)

7.566

12.18–2.951

0.0026

Normalized TNF-α

1.61E−7 (3.0E−7)

3.42E−7 (2.97E−7)

1.81E−7

4.38E−7 to − 7.55E−8

n.s.

TGF-β1 (ng/ml)

0.4504 (0.8607)

1.161 (2.270)

0.7103

2.278 to − 0.857

n.s.

Normalized TGF-β1

1.9E−5 (2.0E−5)

2.4E−5 (2.1E−5)

4.55E−6

2.02E−5 to − 1.5E−5

n.s.

IFN-γ (pg/ml)

0.6463 (1.552)

1.191 (1.357)

0.5446

1.812 to − 0.7226

n.s.

Normalized IFN-γ

2.93E−8 (5.65E−8)

3.42E−8 (2.35E−8)

4.91E−9

4.44E−8 to − 3.45E−8

n.s.

  1. SD standard deviation, PHH: post-hemorrhagic hydrocephalus