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Table 1 Parameter estimates of the S-atenolol pharmacokinetic model in rats

From: Revisiting atenolol as a low passive permeability marker

Parameter Unit Estimate RSE (%) IIV (%) RSE IIV (%)
RECblood % 49.9 3.5 12.2 24.8
RECbrain % 6.73 9.5 27.9 17.2
CL mL/min 10.2 2.4 7.5 16.9
V1 mL 215 10.8 30.3 28.4
Q mL/min 5.56 8.9   
V2 mL 402 4.8   
fu,p   1.0 Fixed   
QAV mL/min 15.4 9.2   
CLin µL/min/gbrain 17.0 48.8 134.2 27.5
Kp,uu,brain   0.040 11.3 35.5 18.0
Vu,brain mL/g brain 0.686 Fixed   
σproportional,RECbrain   0.028 9.4   
σadditive,RECblood ng/mL 7.83 5.1   
σproportional,plasma   0.184 20.3   
σproportional,blood   0.112 8.8   
σproportional,brain   0.0741 12.3   
σadditive,brain ng/mL 0.22 20.2   
  1. RSE relative standard error; IIV Inter-individual variation expressed as coefficient of variation; REC relative recoveries; CL systemic total clearance; V 1 volume of distribution of total arterial and venous compartments; Q clearance between arterial and peripheral compartments; V 2 volume of distribution of the peripheral compartment; f u,p unbound fraction in plasma; Q AV clearance between arterial and venous compartments; Cl in influx clearance into brain; K p,uu,brain unbound partition coefficient in brain; V u,brain unbound volume of distribution in brain; σ variances of the proportional or additive residual errors