From: Revisiting atenolol as a low passive permeability marker
Parameter | Unit | Estimate | RSE (%) | IIV (%) | RSE IIV (%) |
---|---|---|---|---|---|
RECblood | % | 49.9 | 3.5 | 12.2 | 24.8 |
RECbrain | % | 6.73 | 9.5 | 27.9 | 17.2 |
CL | mL/min | 10.2 | 2.4 | 7.5 | 16.9 |
V1 | mL | 215 | 10.8 | 30.3 | 28.4 |
Q | mL/min | 5.56 | 8.9 | ||
V2 | mL | 402 | 4.8 | ||
fu,p | 1.0 | Fixed | |||
QAV | mL/min | 15.4 | 9.2 | ||
CLin | µL/min/gbrain | 17.0 | 48.8 | 134.2 | 27.5 |
Kp,uu,brain | 0.040 | 11.3 | 35.5 | 18.0 | |
Vu,brain | mL/g brain | 0.686 | Fixed | ||
σproportional,RECbrain | 0.028 | 9.4 | |||
σadditive,RECblood | ng/mL | 7.83 | 5.1 | ||
σproportional,plasma | 0.184 | 20.3 | |||
σproportional,blood | 0.112 | 8.8 | |||
σproportional,brain | 0.0741 | 12.3 | |||
σadditive,brain | ng/mL | 0.22 | 20.2 |