Fig. 7
From: Revisiting atenolol as a low passive permeability marker
Simulation of unbound S-atenolol concentrations in arterial plasma (solid line) and in brain ECF (dashed line) for the scenarios of a CLin = CLout = 17 µL/min/g brain, b CLin < CLout, and c CLin = CLout = 0.3 µL/min/g brain (i.e. permeability surface area product of sucrose) with an i.v. infusion of 0.167 mg/min/kg