Fig. 6

Visual predictive check for the final pharmacokinetic model based on 200 simulations for S-atenolol concentrations in blood dialysate (a) and in brain dialysate (b). The pharmacokinetic model involves the transformation of microdialysis data by evaluating probe recoveries, and thus the observed data for the model are the uncorrected drug concentrations in dialysate. Blue circles: observed data; red lines: median and 5th and 95th percentiles for observed data; black dashed line: median line of simulated data; green area: 95% confidence interval for the median simulated data