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Table 2 Cerebrospinal fluid analysis in patients with meningeosis neoplastica

From: Cerebrospinal fluid abnormalities in meningeosis neoplastica: a retrospective 12-year analysis

Parameter

Normal findings

n (%)

Abnormal findings

n (%)

Median (minimum; maximum)

CSF cells (/µl) excluding erythrocytes

66 (50)

66 (50)

4 (0/4692)

CSF protein (mg/l)

28 (21.5)

102 (78.5)

1012 (166/15,840)

QAlbumin × 10−3

37 (30.6)

84 (69.4)

17.5 (1.8/330)

CSF lactate (mmol/l)

46 (34.8)

86 (65.2)

3.6 (1.3/15.6)

  1. In 50% of CSF samples with meningeosis neoplastica the CSF cell count was not elevated. The CSF-to-serum albumin ratio was abnormal in 69.4%, and total CSF protein was elevated (>450 mg/l) in 102 of 130 patients (78.5%). CSF lactate was elevated (>2.4 mmol/l) in 65.2%
  2. In 32.6% breast cancer was the primary malignoma, followed by bronchial carcinomas (25.0%), hematologic malignancies (21.2%), gastrointestinal tumors (8.3%) and neoplasias of the skin (3.8%). All other malignancies including primary brain and spinal tumors accounted for 9.1% of the cases
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Fluids and Barriers of the CNS

ISSN: 2045-8118