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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: Nrf2 signaling increases expression of ATP-binding cassette subfamily C mRNA transcripts at the blood–brain barrier following hypoxia-reoxygenation stress

Fig. 5

Prevention of BBB dysfunction by targeting Mrp isoforms at the BBB. Results from our present study demonstrate increased mRNA expression of Abcc1, Abcc2, and Abcc4 at the BBB following an H/R insult. Furthermore, H/R stress is known to suppress GSH levels and increase GSSG concentrations in the brain. We propose that changes in GSH/GSSG transport occur during H/R as a result of altered functional expression of at least one Mrp isoform. Since Nrf2, a ROS sensitive transcription factor, is known to regulate Mrps, we hypothesize that this pathway is a critical regulatory mechanism for Mrps at the BBB. Our present data show involvement of Nrf2 signalling in regulation of Abcc mRNA transcript expression in rat brain microvessels following H/R. Future studies are ongoing in our laboratory to determine the functional implications of this observation, particularly with respect to GSH transport and redox balance at the BBB. Mrp isoforms where BBB localization has not been confirmed are indicated by (question mark)

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Fluids and Barriers of the CNS

ISSN: 2045-8118