Figure 5
Effects of low density lipoprotein (LDL) and oxLDL treatment on ROS and NO production. Effects of LDL or oxLDL treatment on the reactive oxygen species (ROS) and nitric oxide (NO) production in cells from wild type (Wt) and ApoB-100 transgenic (Tg) mice. A ROS and B NO production of brain endothelial cells (EC), pericytes (PC) and astroglia cells (AC) is shown 1 h after treatment. Hydrogen peroxide (H2O2) served as positive control in the ROS assay, sodium nitroprusside (SNP) served as positive control in the NO assay. C untreated control, OX oxLDL treatment. Values presented are mean ± SD, n = 3–8. Statistical analysis: ANOVA followed by Dunnett and Bonferroni tests. Statistically significant differences: (a) compared to wild type control; (b) compared to transgenic control; *p < 0.05; **p < 0.01; ***p < 0.001 wild type compared to transgenic.