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Figure 2 | Fluids and Barriers of the CNS

Figure 2

From: Differential cytokine expression by brain microglia/macrophages in primary culture after oxygen glucose deprivation and their protective effects on astrocytes during anoxia

Figure 2

Concentration of the M1-specific (A) and M2-specific (B) cytokines in cell culture media collected from control groups and from cultures that were exposed to OGD protocol. As it could be seen from the figure, there was a common pattern of concentration changes after OGD protocol for the M2-specific cytokines (panel B), with their concentration in the medium increasing immediately after the OGD protocol and then decreasing during the recovery period. The opposite pattern was revealed for the two M1-specific cytokines, TNFa and IL-12, with their concentrations being low after OGD protocol and then increasing during the recovery period, reaching the highest values after 10 days (panel A). A pattern for the M1-specific cytokine IL-6 was different, with an initial increase in concentration after the OGD protocol, then decreasing during the recovery period and increasing again between days 5–10. Data are presented as mean ± SEM from 4 samples that were taken from 4 different flasks, * = p < 0.05, ** = P < 0.01, cultures exposed to OGD versus control.

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Fluids and Barriers of the CNS

ISSN: 2045-8118