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Figure 5 | Fluids and Barriers of the CNS

Figure 5

From: Structural defects in cilia of the choroid plexus, subfornical organ and ventricular ependyma are associated with ventriculomegaly

Figure 5

Genesis of ependymal cell primary cilia appears normal in P0 Bbs1M390R/M390Rmice. TEM micrographs of P0 wild- type (A, C, E) and Bbs1M390R/M390R mice (B, D, F) show normal stages of primary cilia formation in the lateral ventricle. The mother centriole (arrow) is surrounded by the secondary centriole and approaches the ependymal plasma membrane (A, B). The cilium (arrow) then docks and fuses with the ependymal plasma membrane (C, D) and elongates via incoming secondary ciliary vesicles and intraflagellar transport (E, F). The ciliary pocket (CP) is evident in panels A, B, and D (arrowhead). The ependyma appears healthy and exhibits tight junctions between cells (*). Bars equal 0.2 μm (A) and 0.5 μm (B-F).

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Fluids and Barriers of the CNS

ISSN: 2045-8118