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Figure 3 | Fluids and Barriers of the CNS

Figure 3

From: Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels

Figure 3

Effect of TCDD on Cyp1a1 and Cyp1b1 mRNA levels in isolated rat brain microvessels. (A) Freshly isolated rat brain microvessels from naïve rats were incubated ex vivo for 3 h with 25 nM TCDD (n = 4 rats per group). (B) Rats were dosed with a single i.p. dose of 25 μg/kg TCDD and brain microvessels were isolated at 72 h (n = 8 rats per group). Data are shown as relative expression of Cyp1a1 or Cyp1b1 mRNA in treated and control rats using q-PCR. Results are expressed as means ± SD ***p < 0.001 (Student's t-test).

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Fluids and Barriers of the CNS

ISSN: 2045-8118