Inhibitor | Â | [14C]GAA uptake | Â | [14C]CTN uptake |
---|---|---|---|---|
 | CRT/HEK293 cells %of control | CRT/oocytes %of control | TauT/oocytes %of control | rOCT3/oocytes %of control |
Control | 100 ± 4 | 100 ± 9 | 100 ± 9 | 100 ± 19 |
Guanidinoacetate (GAA) | 19.2 ± 2.6* | 44.6 ± 2.7* | 53.2 ± 9.6* | - |
β-Guanidinopropionate (GPA) | 1.81 ± 0.14* | 0.944 ± 0.189* | 4.77 ± 0.66* | 143 ± 21 |
γ-Guanidinobutyrate (GBA) | 10.0 ± 0.6* | 21.4 ± 2.0* | 21.7 ± 4.2* | - |
Guanidinoethansulfonate (GES) | 23.1 ± 1.1* | - | 4.66 ± 0.22* | - |
Guanidinosuccinate (GSA) | 101 ± 1 | 107 ± 12 | 103 ± 10 | - |
Creatine (CT) | 3.06 ± 0.24* | 2.91 ± 0.23* | 98.4 ± 12.7 | 137 ± 24 |
Taurine | 111 ± 5 | - | 3.00 ± 0.19* | - |
γ-Aminobutyric acid (GABA) | 95.5 ± 2.9 | - | 34.0 ± 4.6* | - |
Creatinine (CTN) | 93.3 ± 5.3 | 123 ± 10 | 97.9 ± 14.6 | - |
Methylguanidine (MG) | 82.3 ± 15.2 | 126 ± 14 | 110 ± 18 | 47.2 ± 18.9** |
Creatine phosphate (PCT) | 93.4 ± 6.8 | 97.9 ± 14.1 | 117 ± 6 | - |
Guanidine | 114 ± 6 | 88.2 ± 13.4 | - | 137 ± 22 |
L-Arginine | 86.6 ± 6.3 | - | - | - |
Glycine | 126 ± 4 | - | - | - |
L-Alanine | 111 ± 3 | - | - | - |
L-Aspartic acid | 98.5 ± 2.2 | - | - | - |
Tetraethylammonium | 128 ± 29 | 82.8 ± 7.3 | - | 48.1 ± 8.3** |
Benzylpenicillin | 110 ± 14 | 115 ± 12 | - | - |