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Volume 12 Supplement 1

Abstracts from Hydrocephalus 2015

Calcium antagonism effects on cerebral blood flow in rats with acute hydrocephalus

Introduction

Calcium ion antagonism shows some benefit in experimental hydrocephalus, but the interrelationship between the cerebral vasculature, cerebral blood flow (CBF), and ventriculomegaly remains unclear.

Methods

Rats were injected with kaolin at 35 days and were studied after 12-15 days. CBF was measured with and without nimodipine or magnesium sulfate using magnetic resonance and fluorescent microspheres. Arterial blood and intracranial pressure (ICP), acid-base, oxygen/hemoglobin, and electrolytes status was measured. Intraparenchymal vascular remodeling was also determined in brains of hydrocephalic rats treated with calcium antagonists for 2 weeks.

Results

Increased ICP did not significantly affect cerebral perfusion pressure within the range of normal autoregulation. CBF significantly decreased in acutely hydrocephalic rats. Nimodipine and magnesium sulfate decreased systemic arterial blood pressure, cerebral perfusion and intracerebral pulse pressure; however, there was no change in cerebral blood flow. There was no change in white matter vascular density after 2 weeks treatment.

Conclusions

Cerebral hypoperfusion occurs in acute experimental hydrocephalus, however the calcium channel antagonists nimodipine and magnesium sulfate, do not increase the CBF. Reduced intracranial pulse pressure possibly mitigates development of acute hydrocephalus.

References

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Correspondence to Alexander Victor Shulyakov.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Shulyakov, A.V., Buist, R.J., DiCurzio, D.L. et al. Calcium antagonism effects on cerebral blood flow in rats with acute hydrocephalus. Fluids Barriers CNS 12, P49 (2015). https://doi.org/10.1186/2045-8118-12-S1-P49

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Keywords

  • Cerebral Blood Flow
  • Hydrocephalus
  • Kaolin
  • Cerebral Perfusion
  • Nimodipine