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Volume 12 Supplement 1

Abstracts from Hydrocephalus 2015

  • Poster presentation
  • Open Access

Calcium antagonism effects on cerebral blood flow in rats with acute hydrocephalus

  • 1, 2Email author,
  • 3,
  • 2, 4 and
  • 1, 2
Fluids and Barriers of the CNS201512 (Suppl 1) :P49

  • Published:


  • Cerebral Blood Flow
  • Hydrocephalus
  • Kaolin
  • Cerebral Perfusion
  • Nimodipine


Calcium ion antagonism shows some benefit in experimental hydrocephalus, but the interrelationship between the cerebral vasculature, cerebral blood flow (CBF), and ventriculomegaly remains unclear.


Rats were injected with kaolin at 35 days and were studied after 12-15 days. CBF was measured with and without nimodipine or magnesium sulfate using magnetic resonance and fluorescent microspheres. Arterial blood and intracranial pressure (ICP), acid-base, oxygen/hemoglobin, and electrolytes status was measured. Intraparenchymal vascular remodeling was also determined in brains of hydrocephalic rats treated with calcium antagonists for 2 weeks.


Increased ICP did not significantly affect cerebral perfusion pressure within the range of normal autoregulation. CBF significantly decreased in acutely hydrocephalic rats. Nimodipine and magnesium sulfate decreased systemic arterial blood pressure, cerebral perfusion and intracerebral pulse pressure; however, there was no change in cerebral blood flow. There was no change in white matter vascular density after 2 weeks treatment.


Cerebral hypoperfusion occurs in acute experimental hydrocephalus, however the calcium channel antagonists nimodipine and magnesium sulfate, do not increase the CBF. Reduced intracranial pulse pressure possibly mitigates development of acute hydrocephalus.

Authors’ Affiliations

Department of Pathology, University of Manitoba, Canada
Manitoba Institute of Child Health, Winnipeg, Canada
Department of Radiology, Faculty of Medicine, University of Manitoba, Canada
Department of Human Anatomy & Cell Science, University of Manitoba, Canada


  1. Alfasi AM, Shulyakov AV, Del Bigio MR: Intracranial biomechanics following cortical contusion in live rats. J Neurosurg. 2013, 119 (5): 1255-62. 10.3171/2013.7.JNS121973. doi: 10.3171/2013.7.JNS121973. Epub 2013 Sep 13View ArticlePubMedGoogle Scholar
  2. Shulyakov AV, Del Bigio MR: Neurosurgery. 2013, 72 (5): E877-8. 10.1227/NEU.0b013e31828ab43c. doi: 10.1227/NEU.0b013e31828ab43cView ArticlePubMedGoogle Scholar
  3. Shulyakov AV, Buist RJ, Del Bigio MR: Intracranial biomechanics of acute experimental hydrocephalus in live rats. Neurosurgery. 2012, 71 (5): 1032-40. 10.1227/NEU.0b013e3182690a0c. doi: 10.1227/NEU.0b013e3182690a0cView ArticlePubMedGoogle Scholar


© Shulyakov et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.