Volume 12 Supplement 1
Bradykinesia in idiopathic normal pressure hydrocephalus evaluated by quantitative finger tapping test: preliminary study
© Nishida et al. 2015
Published: 18 September 2015
Movement disorders in idiopathic normal pressure hydrocephalus (iNPH) are represented by gait disturbance (i.e., lower body bradykinesia). However, upper extremity bradykinesia was frequently found among iNPH patients. We assessed their upper extremity function by quantitative finger tapping test and checked the correlation with other demographic factors.
We evaluated the 10-second finger tapping movements of 8 patients (age: 78.4 ± 3.8 y; males: 5, females: 3) using magnetic-sensor coil system. Clinical symptoms were evaluated by the iNPH grading scale, mini-mental state examination and frontal assessment battery (FAB). The correlation of tapping parameters with clinical indicators was estimated.
The patient's age correlated significantly with 6 of 21 finger-tapping parameters, including total tapping distance (Spearman r = -0.82, p = 0.013), coefficient of variation of maximum amplitude (r = -0.78, p = 0.023), energy balance (r = -0.72, p = 0.046), average maximum opening acceleration (r = -0.75, p = 0.034), tapping frequency (r = -0.85, p = 0.005), and average finger tapping interval (r = 0.87, p = 0.007). The severity of illness represented by iNPH grading scale correlated with other 2 parameters, including average maximum closing velocity (r = -0.73, p = 0.043) and coefficient of variation of maximum closing velocity (r = -0.79, p = 0.047).
Our data support the diagnostic value of quantitative finger tapping test for estimating the severity of bradykinesia underlying the iNPH symptomatology. Though preliminary, different patterns of correlations found in this study could potentially indicate the fundamental processes discriminating aging and disease progression.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.