Volume 12 Supplement 1
Surgical indication of iNPH (idiopathic normal pressure hydrocephalus)
© Kimura et al. 2015
Published: 18 September 2015
Some patients with iNPH often can recover independent AD and can be easily rehabilitated after shunt surgery. However, other patients sometimes cannot recover independent ADL even if improvement is obtained after treatment, because of some factors. The purpose of this study is to examine the influence of the factor determining the benefit from shunt surgery.
All patients underwent a tap test during 9 years from 2002 to 2010, and 154 probable iNPH patients who showed a clinical improvement of at least 10% underwent shunt placement (V-P shunt, 12 patients; L-P shunt, 142 patients). One hundred and thirty-three patients who could be followed up for one year were investigated for age, the interval from onset to surgery, severity, degree of improvement by tap test, MRI findings (DESH or non-DESH).
According to older patients, the postoperative recovery of mRS, gait disturbance (GD), dysuria, and cognitive impairment (CI) was poor. According to long interval from onset to surgery (group 1<2<3<4<5), the score (mRS, iNPHGS) of them showed higher points mean more severity. There were correlations between the length of the interval from onset to surgery and severity (P<0.01), between the length of the interval from onset to surgery and the degree of improvement after surgery (P<0.01), and between severity and the degree of improvement after shunt (P<0.01). There were correlations between severity of GD (P<0.01) and the degree of improvement after surgery. In tap test, the patient (group A) of remarkable recovery of postoperative score, the symptom was improved, especially, mRS, GD significantly (P<0.01), keeping good ADL after one year (p<0.01). The patient with DESH in preoperative MRI findings (coronal view) was more improvement than patients with non-DESH in mRS, GD, dysuria and CI, significantly (p<0.01), keeping good independent ADL after one year postoperatively.
Surgical indication is decided with careful consideration of social indication including the comorbidity, fully informed consent should be made.
- In vivo single-voxel proton MR spectroscopy in brain lesions with ring-like enhancement. NMR Biomed. 2001, 14 (6): 339-49. 10.1002/nbm.711.Google Scholar
- Effect of mild hypothermia on energy state recovery following transient forebrain ischemia in the gerbil. Exp Brain Res. 2002, 1 (2): 121-4.Google Scholar
- Diagnosis and treatment of progressive space-occupying radiation necrosis following stereotactic radiosurgery for brain metastasis: value of proton magnetic resonance spectroscopy. Acta Neurochir (Wien). 2003, 145 (7): 557-64. 10.1007/s00701-003-0051-0.Google Scholar
- Evaluation of the response of metastatic brain tumors to stereotactic radiosurgery by proton magnetic resonance spectroscopy, 201TlC1 single-photon emission computerized tomography, and gadolinium-enhanced magnetic resonance imaging. J Neurosurg. 2004, 100: 835-841. 10.3171/jns.2004.100.5.0835.Google Scholar
- Multiple basilar artery trunk aneurysms associated with fibromuscular dysplasia. Acta Neurochir (Wien). 2004, 146: 79-81. 10.1007/s00701-003-0163-6.Google Scholar
- Increase in glutamate as a sensitive indicator of extracellular matrix integrity in peritumoral edema: a 3.0-tesla proton magnetic resonance spectroscopy study. J Neurosurg. 2007, 106: 609-613. 10.3171/jns.2007.106.4.609.Google Scholar
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