- Oral presentation
- Open Access
Exercise-induced changes of CSF vascular endothelial growth factor in adult chronic hydrocephalus patients
© Luciano et al. 2015
- Published: 18 September 2015
- Vascular Endothelial Growth Factor
- Vascular Endothelial Growth Factor Receptor
- Exercise Group
- Vascular Endothelial Growth Factor Level
Vascular endothelial growth factor (VEGF) is a growth factor demonstrated to play a key role in cerebral angiogenesis and neurogenesis. It has been considered a critical component in hippocampus neurogenesis and memory formation and has been observed to increase in the rat hippocampus after exercise. In a previous study, we found increases in VEGF receptor and/or ligand in an experimental model of chronic e hydrocephalus in several brain areas and cerebrospinal fluid (CSF), suggesting a role in the adaption to chronic hypoxia. Here we investigate the ability of moderate exercise to increase CSF-VEGF levels in adult chronic hydrocephalus patients.
Lumbar CSF samples were collected from 17 normal pressure hydrocephalus (NPH) patients over 5 hours in 1-h intervals. During CSF collection, 11 patients (exercise group) underwent a standard in-room physical therapy session; 6 patients (no-exercise group) did not undergo a physical therapy session. CSF-VEGF levels were evaluated for increase related to exercise and the clinical response to CSF drainage.
CSF-VEGF levels in the exercise group demonstrated significant increases 1-3hrs post-exercise compared with the levels 1-2hrs pre-exercise (p=0.04), and also showed significantly higher levels than the no-exercise groups (p=0.03). While patients who clinically improved with CSF removal did not demonstrate an increase in CSF-VEGF levels, those who did not clinically improve had higher CSF-VEGF levels after exercise. The post-exercise CSF-VEGF level in the group that did not clinically improvement was significantly higher than both their own pre-exercise level (p=0.02) and also higher than that seen in the clinically improving group (p=0.05) after exercise.
CSF-VEGF levels can increase after moderate exercise even in elderly hydrocephalus patients. This suggests a potential benefit of exercise in benefiting some of these patients may exist via a central VEGF mechanism. Increased VEGF levels after exercise in patients who showed no improvement with CSF drainage suggest that vascular injury may play a role in this group's pathophysiology.
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