Skip to main content

Volume 12 Supplement 1

Abstracts from Hydrocephalus 2015

  • Oral presentation
  • Open access
  • Published:

The role of perfusion and diffusion MRI in the management of patients affected by probable iNPH: A cohort-prospective preliminary study


Two invasive tests are mainly used to select patients affected by NPH for surgery: measuring resistance to CSF outflow and Tap Test. Cerebral blood flow (CBF) have been demonstrated to be reduced in iNPH patients, mainly in basal ganglia (BG) and periventricular white matter (PVWM) regions. Perfusion MRI might be of value as a diagnostic and predictive tool. The rule of diffusion MRI in determining brain damage in PVWM and BG areas have been investigated. The aim of this study is to identify relationship between cerebral perfusion and microstructural damage of brain tissue measured by perfusion and diffusion MRI in PVWM and BG areas before and after tap-test and after sugery in patients who underwent VP shunt.


23 patients were included in this study. MRI related rCBF and apparent diffusion coefficient (ADC) were calculated in all the cases. Regions of interest were located in PVWM and BG areas. Each patient underwent lumbar infusion test and tap test. After these tests were performed, patients have been clinically evaluated and another MRI was performed with the same protocol. Patients have been then divided into two groups: the first cohort that improved after Tap test, and the second one that did not. Only the first group underwent surgery and were clinically and radiological assessed again a month after VP shunt implantation. A descriptive statistical study was performed using non parametrical tests.


All the 13 patients surgically treated presented a clinical improvement after surgery; an significative increase in rCBF in both periventricular and basal ganglia regions after tap-test and surgery; a decrease in ADC values in periventricular region and an increase in ADC values in basal ganglia regions. The 10 negative patients shown a reduction in rCBF in both PVWM and BG after tap-test; a decrease in ADC values in PVWM and an increasing in ADC values in BG region.


Since trend of rCBF acquired by perfusion MRI agreed with invasive tests results it could be considered a predictive and effective method in the management of patients with probable iNPH. Authors hypothesized decrease in ADC value in PVWM region as a reduction of transependimal edema; and increase in ADC value in basal ganglia area as a reduction in chronic cytotoxic edema due to chronic blood flow impairment.


  1. Vindigni M, Tuniz F, Ius T, Cramaro A, Skrap M: Endoscopic third ventriculostomy in patients with secondary triventricular hydrocephalus from a haemorrhage or ischaemia in the posterior cranial fossa. Minim Invasive Neurosurg. 2010, 53 (3): 106-11. 10.1055/s-0030-1251983.

    Article  CAS  PubMed  Google Scholar 

  2. Skrap M, Tuniz F: Use of the arachnoid membrane of the cerebellopontine angle to transpose the superior cerebellar artery in microvascular decompression for trigeminal neuralgia: technical note. Neurosurgery. 2010, 66 (3 Suppl Operative): 88-91.

    PubMed  Google Scholar 

  3. Tuniz F, Soltys SG, Choi CY, Chang SD, Gibbs IC, Fischbein NJ, Adler JR: Multisession cyberknife stereotactic radiosurgery of large, benign cranial base tumors: preliminary study. Neurosurgery. 2009, 65 (5): 898-907. 10.1227/01.NEU.0000359316.34041.A8.

    Article  PubMed  Google Scholar 

  4. Mucchiut M, Valentinis L, Tuniz F, Zanotti B, Skrap M, Bergonzi P, Zanchin G: Adult aqueductal stenosis presenting as a thunderclap headache: a case report. Cephalalgia. 2007, 27 (10): 1171-3. 10.1111/j.1468-2982.2007.01379.x.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Francesco Tuniz.

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tuniz, F., Vescovi, M.C., DeColle, M.C. et al. The role of perfusion and diffusion MRI in the management of patients affected by probable iNPH: A cohort-prospective preliminary study. Fluids Barriers CNS 12 (Suppl 1), O23 (2015).

Download citation

  • Published:

  • DOI: