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Figure 5 | Fluids and Barriers of the CNS

Figure 5

From: Vascular endothelial growth factor blockade alters magnetic resonance imaging biomarkers of vascular function and decreases barrier permeability in a rat model of lung cancer brain metastasis

Figure 5

Bevacizumab decreases AIB passive permeability. A) The % delivered dose of 14C-AIB was measured in tumor, brain around tumor (BAT), brain distant from tumor (BDT) and contralateral left hemisphere (LH) in saline control and bevacizumab-treated rats with intracerebral A549 xenografts. Bevacizumab decreased AIB concentration in the tumor mass compared to saline control (* P = 0.04) but the effect was not significant in other brain regions. Data are indicated as mean ± SEM of % delivered dose. B) Correlation of AIB concentration with Ktrans measurements of vascular permeability.

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Fluids and Barriers of the CNS

ISSN: 2045-8118