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Figure 4 | Fluids and Barriers of the CNS

Figure 4

From: Vascular endothelial growth factor blockade alters magnetic resonance imaging biomarkers of vascular function and decreases barrier permeability in a rat model of lung cancer brain metastasis

Figure 4

Bevacizumab decreases tumor vessel permeability. Ktrans as a measure of vascular permeability was determined using dynamic contrast-enhanced MRI. A) Representative Ktrans maps of A549 intracerebral xenografts before and after saline (SAL) or bevacizumab (BEV). B) Normalized change in Ktrans in the saline control and bevacizumab-treated animals (n = 8 per group). Data are shown as mean ± standard error of the mean change from baseline. * P < 0.05 versus saline control group. C) Pretreatment and post-treatment Ktrans values in individual rats in the saline (black) and bevacizumab (red) groups.

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Fluids and Barriers of the CNS

ISSN: 2045-8118