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Figure 2 | Fluids and Barriers of the CNS

Figure 2

From: Vascular endothelial growth factor blockade alters magnetic resonance imaging biomarkers of vascular function and decreases barrier permeability in a rat model of lung cancer brain metastasis

Figure 2

Bevacizumab blocks the increase in edema in A549 xenografts. The longitudinal relaxation rate (R1) prior to gadolinium-based contrast agent is inversely proportional to free water (edema). A) R1 maps in representative intracerebral A549 human lung adenocarcinoma xenografts (right hemisphere) compared to a matched region of interest in the control left hemisphere are shown before and after treatment with saline (SAL) or bevacizumab (BEV). B) Normalized change in R1 within the tumor region of interest in saline control and bevacizumab-treated tumors (n = 8 per group). Data are shown as mean ± standard error of the mean change from baseline. * P = 0.033 versus saline control group.

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Fluids and Barriers of the CNS

ISSN: 2045-8118