Figure 3
Distribution of CSF-borne substances within the brain. A. The autoradiogram shows the CSF-brain distribution of 125I-labeled soluble amyloid β-peptide (I-sAβ) 30 min after unilateral intracerebroventricular administration. The radioactive material was mostly visible around pial vessels (arteries) within the interpeduncular, ambient and quadrigeminal cisterns. The appreciable amounts were also present in the lateral recesses of the fourth ventricle (not shown) and along the ventral wall of the aqueduct. B. The histological microphotograph of adjacent coronal section of the brain with attached pituitary gland (Hip–hippocampus; SC - superior colliculus; V–large central vein; Pial V–small pial veins; Pial Ar–pial arteries; Aq–aqueduct, (adapted with permission from [48]).