Figure 2From: Potential for intranasal drug delivery to alter cerebrospinal fluid outflow via the nasal turbinate lymphaticsIntracranial pressure and CSF outflow relationships upon intranasal delivery of pharmacological agents. Shown are representative examples of pressure/flow curves of (A) saline delivery, (B) noradrenaline (NA) at 50 μM and 500 μM, (C) L-NMMA treated at 10 μM and 100 μM and (D) U46619 treated at 0.1 μM and 1.0 μM and (E) U46619 at 1 mM. (A to D) In each experiment (○) represents no treatment (NT), (□) represents the first intranasal delivery, and (×) represents the second intranasal delivery. (E) No treatment is represented by (○), and 1 mM U46619 represented by (□). Linear regression lines for each treatment are shown.Back to article page