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Figure 1 | Fluids and Barriers of the CNS

Figure 1

From: Gene expression-based comparison of the human secretory neuroepithelia of the brain choroid plexus and the ocular ciliary body: potential implications for glaucoma

Figure 1

Molecular network of genes expressed significantly more highly in the brain choroid plexus epithelium compared to the non-pigmented epithelium of the eye. Example of a molecular network generated by Ingenuity software. Grey symbols represent genes expressed more highly in the CPE than in the NPE. Transparent entries are molecules inserted by the knowledge database. Gene names are abbreviated according to those used in GenBank. Solid lines between molecules indicate direct physical or functional relationships between molecules (such as regulating and interacting protein domains). The genes DNAH5, DNAH9, DNAH11 and DNAI2 indicated in bold, code for dynein proteins. Dyneins keep the microtubules of the cilia together and promote the movement of the cilia. Mutations in these genes can cause primary ciliary dyskinesia. The main functionalities given by Ingenuity for this entire molecular network are “Developmental and hereditary disorder and respiratory disease”. Reproduced with permission.

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Fluids and Barriers of the CNS

ISSN: 2045-8118