Table 5 Cerebral malaria (CM)-associated pro-inflammatory molecules known/hypothesized to be matrix metalloproteinase (MMP) substrates
MMP | MMP substrate: cytokine | MMP substrate: chemokine |
|---|---|---|
MMP-1 | IL-1β | CCL-2/MCP-1/JE |
TNF-α | CCL-25/TECK | |
MMP-2 | IL-1β | CCL-2/MCP-1/JE |
TGF-β | CCL-11/Eotaxin | |
TNF-α | CCL-25/TECK | |
CXCL-1/GRO-α/KC | ||
CXCL-2/GRO-β/MIP-2 | ||
CXCL-12/SDF- 1 | ||
MMP-3 | proIL-1β | CCL-2/MCP-1/JE |
proTNF-α | ||
MMP-7 | proTNF-α | |
MMP-8 | CCL-2/MCP-1/JE | |
CXCL-5/ENA-78/LIX | ||
MMP-9 | IL-1β | CXCL-1/GRO-α/KC |
IL2-R | CXCL-2/GRO-β/MIP-2 | |
TGF-β | CXCL-4/PF-4 | |
proTNF-α | CXCL-5/ENA-78/LIX | |
CXCL-10/IP-10 | ||
CXCL-12/SDF- 1 | ||
CCL-5/RANTES | ||
CCL-7/MCP-3/MARC | ||
CCL-17/TARC | ||
CCL-25/TECK | ||
MMP-10 | CCL-25/TECK | |
MMP-11 | CCL-25/TECK | |
MMP-12 | CXCL-3/GRO-γ | |
CXCL-9/MIG | ||
CXCL-10/IP-10 | ||
CXCL-11/I-TAC | ||
MMP-14 | proTNF-α | CXCL-8/IL-8 |
CXCL-12/SDF- 1 |