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Table 4 Cerebral malaria (CM)-associated brain inter-endothelial junctions and cell-matrix adhesion molecules known/hypothesized to be matrix metalloproteinase (MMP) substrates

From: Host matrix metalloproteinases in cerebral malaria: new kids on the block against blood–brain barrier integrity?

MMP

MMP substrate: junctions

Junction type

MMP-1

Collagen I/II/III/VII/VIII/X; Aggrecan; Entactin; Tenascin

Cell-matrix adhesion

MMP-3

Collagen II/IV/IX/X; Claudin-5; E-cadherin; Elastin; Fibronectin; Laminin; Occludin; Selectin; ZO-1

Cell-matrix adhesion; Adherens junctions; Tight junctions

MMP-8

Collagen I/II/III/V/VII/VIII/X; Claudin-5; Laminin; Occludin; ZO-1

Cell-matrix adhesion; Tight junctions

MMP-9

Collagen IV/V/VII/X/XIV; Aggrecan; Claudin-5; E-cadherin; Elastin; Fibronectin; Laminin; Occludin; Vitronectin; ZO-1

Cell-matrix adhesion; Adherens junctions; Tight junctions

MMP-12

Elastin; Fibronectin; Laminin; Proteoglycans

Cell-matrix adhesion

MMP-13

Collagen I/II/III/IV/V/IX; Aggrecan; Elastin; Fibronectin; Laminin; Tenascin

Cell-matrix adhesion

MMP-14

Collagen I/II/III; E-cadherin; αvβ4 integrin; Aggrecan; Fibronectin; Laminin; Vitronectin

Cell-matrix adhesion; Adherens junctions