Table 4 Cerebral malaria (CM)-associated brain inter-endothelial junctions and cell-matrix adhesion molecules known/hypothesized to be matrix metalloproteinase (MMP) substrates
MMP | MMP substrate: junctions | Junction type |
|---|---|---|
MMP-1 | Collagen I/II/III/VII/VIII/X; Aggrecan; Entactin; Tenascin | Cell-matrix adhesion |
MMP-3 | Collagen II/IV/IX/X; Claudin-5; E-cadherin; Elastin; Fibronectin; Laminin; Occludin; Selectin; ZO-1 | Cell-matrix adhesion; Adherens junctions; Tight junctions |
MMP-8 | Collagen I/II/III/V/VII/VIII/X; Claudin-5; Laminin; Occludin; ZO-1 | Cell-matrix adhesion; Tight junctions |
MMP-9 | Collagen IV/V/VII/X/XIV; Aggrecan; Claudin-5; E-cadherin; Elastin; Fibronectin; Laminin; Occludin; Vitronectin; ZO-1 | Cell-matrix adhesion; Adherens junctions; Tight junctions |
MMP-12 | Elastin; Fibronectin; Laminin; Proteoglycans | Cell-matrix adhesion |
MMP-13 | Collagen I/II/III/IV/V/IX; Aggrecan; Elastin; Fibronectin; Laminin; Tenascin | Cell-matrix adhesion |
MMP-14 | Collagen I/II/III; E-cadherin; αvβ4 integrin; Aggrecan; Fibronectin; Laminin; Vitronectin | Cell-matrix adhesion; Adherens junctions |