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Table 4 mRNA expression levels of organic cation transporters in hCMEC/D3cells determined by quantitative RT-PCR analysis

From: Functional expression of a proton-coupled organic cation (H+/OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood–brain barrier model

Target mRNA

mRNA expression

 

(target mRNA x 105/GAPDH mRNA)

hOCT1/SLC22A1

1.99 ± 0.21

hOCT2/SLC22A2

N. D.

hOCT3/SLC22A3

8.59 ± 0.55

hOCTN1/SLC22A4

80.7 ± 4.6

hOCTN2/SLC22A5

248 ± 7.3

hMATE1/SLC44A1

0.29 ± 0.02

hMATE2/SLC44A2

1.15 ± 0.16

hPMAT/SLC29A4

34.0 ± 2.4

  1. Each value represents the mean ± S.E. of eight determinations. N.D.: not detected.
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Fluids and Barriers of the CNS

ISSN: 2045-8118