Figure 5
The influx of 125I-FGF19 from blood to peripheral organs after iv injection. (A) In the liver, there was a rapid influx of 125I-FGF19 (Ki = 223.60 ± 55.47 μl/g-min). The presence of 56-fold excess unlabeled FGF19 produced a significant reduction of the Ki which remained linear and higher than that of the vascular space marker 131I-albumin. (B) In the kidney, the basal uptake of 125I-FGF19 was highly variable and not significantly different from zero. The presence of excess unlabeled FGF19 resulted in a linear clearance of 125I-FGF19 but did not change the minimal uptake of 131I-albumin. Each time point indicates an individual mouse (n = 8/group).