Molecular name | Protein expression level (fmol/μg protein) | ||
---|---|---|---|
ddY | FVB | C57BL/6J | |
ABC transporters | |||
Abcb1a (Mdr1a/P-gp) | 16.4 ± 1.3c | 14.2 ± 1.6e | 17.8 ± 1.2 |
Abcc1 (Mrp1) | U.L.Q. (< 0.123)c | U.L.Q. (< 0.080)e | U.L.Q. (< 0.121) |
Abcc4 (Mrp4) | 1.33 ± 0.14c | 1.27 ± 0.21e | 1.51 ± 0.27 |
Abcc5 (Mrp5) | U.L.Q. (< 0.497)c | U.L.Q. (< 0.412)e | U.L.Q. (< 0.544) |
Abcc6 (Mrp6) | U.L.Q. (< 0.478)c | U.L.Q. (< 0.406)e | U.L.Q. (< 0.312) |
Abcg2 (Bcrp) | 3.74 ± 0.32c | 3.21 ± 0.49e | 5.48 ± 0.37a |
SLC transporters | |||
Slc2a1 (Glut1) | 82.1 ± 3.0c | 90.9 ± 3.9e | 101 ± 4 |
Slc7a5 (Lat1) | 2.54 ± 1.55c | 2.11 ± 0.82e | 1.17 ± 0.36 |
Slc16a1 (Mct1) | 17.3 ± 1.3c | 19.9 ± 1.0e | 13.7 ± 0.5b |
Slc21a2 (Pgt) | U.L.Q. (< 0.304) | U.L.Q. (< 0.277) | U.L.Q. (< 0.309) |
Slc22a8 (Oat3) | 1.78 ± 0.15c | 1.65 ± 0.52e | 2.29 ± 0.40 |
Slc29a4 (Pmat) | U.L.Q. (< 0.220) | U.L.Q. (< 0.194)e | U.L.Q. (< 0.193) |
Receptors | |||
Insr | 0.738 ± 0.212d | 0.637 ± 0.080e | 1.13 ± 0.18 |
Lrp1 | 1.36 ± 0.42d | 0.981 ± 0.072e | 1.37 ± 0.33 |
Tfr1 | 4.34 ± 0.81d | 3.89 ± 0.66e | 5.22 ± 0.47 |
Tight junction protein | |||
Claudin-5 | 6.16 ± 0.20 | 5.50 ± 0.49e | 8.07 ± 1.47 |
Marker proteins | |||
Na+/K+-ATPase | 39.5 ± 1.9c | 32.3 ± 1.3e | 39.0 ± 0.9 |
γ-gtp | 3.01 ± 0.47c | 2.45 ± 0.12e | 3.17 ± 0.36 |