The mastermind approach to CNS drug therapy: translational prediction of human brain distribution, target site kinetics, and therapeutic effects

Table 1 Physico-chemical properties of acetaminophen and quinidine

Compound	MW	PSA	logP	logD[7.4]	pKa1 [Acid]	pKa2 [Acid]	pKa1 [Base]	pKa1 [Base]	Ionized at physiological pH	Substrate for
Acetaminophen	151	49,3	0,25	0,23				10,2	0% [neutral]	-
Quinidine	324	45,6	2,29	1,4	4,2		8		99.8% [positive]	Pgp

MW = molecular weight, PSA = polar surface area, Log P = measure of lipophilicity determined as log of partition of un-ionised compound over octanol/water, Log D[7.4] = measure of lipophilicity at physiological pH, determined as log of distribution of the compound over octanol/ buffer pH = 7.4.

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