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Figure 7 | Fluids and Barriers of the CNS

Figure 7

From: The mastermind approach to CNS drug therapy: translational prediction of human brain distribution, target site kinetics, and therapeutic effects

Figure 7

Brain distribution of remoxipride (REM) in the rat following intravenous (IV) and intranasal (IN) administration. Observed data points for plasma and brain ECF concentrations in the rat following intranasal and intravenous administration of remoxipride (open circles), and the “visual predictive check (VPC)” of the median concentration predictions of the model (black line), and the 90% prediction intervals (grey area). The VPC indicated that the model adequately described the observed data (from [147] with permission).

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Fluids and Barriers of the CNS

ISSN: 2045-8118