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Table 1 Cortical thickness of all regions (parietal, occipital 1 and occipital 2) and locations (dorsal, lateral and temporal) in the four groups of experimental animals (n = 5 for all groups).

From: Minocycline inhibits glial proliferation in the H-Tx rat model of congenital hydrocephalus

 

Mean cortical thickness in mm ± SD

Cortical Region

Control no minocycline

Control with minocycline

Untreated hydrocephalic

Minocycline-treated hydrocephalic

Parietal

    

   Dorsal

1.44 ± 0.13

1.32 ± 0.27

0.55 ± 0.27 +++

0.76 ± 0.34 ββ, #, δδ

   Lateral

1.78 ± 0.11

1.41 ± 0.14

0.71 ± 0.32

1.12 ± 0.67

   Temporal

1.59 ± 0.21

1.79 ± 0.53

0.33 ± 0.16 +++

0.58 ± 0.37 βββ, ###, δδδ

Occipital 1

    

   Dorsal

1.26 ± 0.13

1.25 ± 0.18

0.34 ± 0.09**

0.61 ± 0.15 βββ, ###,δδδ

   Lateral

1.29 ± 0.11

1.23 ± 0.12

0.35 ± 0.12 *, +++

0.74 ± 0.28

   Temporal

1.24 ± 0.14

1.17 ± 0.30

0.21 ± 0.12 **, +++

0.59 ± 0.24

Occipital 2

    

   Dorsal

2.04 ± 0.27

1.04 ± 0.15

0.33 ± 0.09 *, +++

0.45 ± 0.11 ββ, ##, δδ

   Lateral

3.60 ± 0.78

1.29 ± 0.42

0.28 ± 0.14 +++

0.48 ± 0.24 βββ, ###, δδδ

   Temporal

3.47 ± 0.31

1.31 ± 0.64

0.31 ± 0.11 ++

0.48 ± 0.23 ββ, ###, δδ

  1. *, **, p < 0.05 and 0.01; Untreated hydrocephalic compared to control no minocycline.
  2. ++, +++, p < 0.01 and 0.001; Untreated hydrocephalics compared to control with minocycline.
  3. ββ, βββ, p < 0.01 and 0.001; Minocycline-treated hydrocephalic compared to untreated hydrocephalic.
  4. #, ##, ###, p < 0.05, 0.01 and 0.001; Minocycline-treated hydrocephalic compared to control no minocycline.
  5. δ δ, δ δ δ, p < 0.01 and 0.001; Minocycline-treated hydrocephalic compared to control with minocycline.