Cerebrospinal fluid markers in Creutzfeldt-Jakob disease

Table 1 Characteristics and results for patients with Creutzfeldt-Jakob disease

Sex/age (years)	Disease duration¹ (months)	EEG	MR	Autopsy	tTau (ng/L)	P-Tau⁴ (ng/L)	tTau/P- Tau (ng/L)	Aβ₄₂ ⁵ (ng/L)	14-3-3 protein
Female/84	2	TSWC²	NC⁸	Denied	7,090	49	173	664	Not done
Male/75	6	TSWC	NC	Denied	13,830	211*	65	385*	Positive⁷
Male/62	4	GD⁶	NC	Not done	12,910	149*	83	372*	Not done
Female/58	22	GD	NC	Denied	1,880	92*	26	623	Positive⁷
Female/77	3	TSWC	HSC⁹	Positive³	3120	45	69	704	Positive⁷
Female/67	4	TSWC	HSC	No result	8532	66	129	526*	Positive⁷ 0.96
Female/64	Rapid	TSWC	HSC	Positive biopsy ³	14,060	84*	167	562	Positive⁷ 3.68
Male/74	2	GD	HSC	Not done	22,460	82*	274	946	2.42
Female/65	>23	TSWC	HSC	Not done	1,343	72	193	M	0.30
Female/70	15	TSWC	HSC	Not done	2,348	93*	25	1051	0.35
Female/61	Rapid	TSWC	HSC	No result	11,038	48	230	755	1.75
Male/54	5	TSWC	HSC	No result	71,900	172*	97	1042	Positive⁷ 9.70

¹The time from disease recognition to death, ²Three-phase sharp wave complexes, ³Positive for immunochemical examination of pathological prion protein, PrP^Sc, ⁴Values above the normal limit used in clinical practice marked with *, ⁵Values below the normal limit used in clinical practice marked with*, ⁶Generalized dysrythmia, ⁷14-3-3 protein found positive in different laboratories outside Norway because some hospitals sent CSF samples for 14-3-3 protein analysis to laboratories outside Norway in parallel to sending samples to us. (Three patients both have semi quantitative results from us and a qualitative, positive result, from a foreign laboratory). ⁸NC, non-specific changes. ⁹HSC, highly suggestive changes of CJD, M = missing value.

ISSN: 2045-8118