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Table 1 Baseline characteristics of the seven AD-NPH subjects. The imaging studies were read by an independent neuroradiologist. The normal MDRS score is 142–144, the normal MMSE score is 27–30. Consequently, these patients are in the mild to moderate range of AD.

From: Elevated cerebrospinal fluid pressure in patients with Alzheimer's disease

Subject number 1 2 3 4 5 6 7
Age 68 66 63 71 73 56 70
Gender Male Female Female Male Male Female Male
Highest Education <8th Grade 8th – 12th Grade >12th Grade >12th Grade 8th -12th Grade 8th – 12th Grade 8th – 12th Grade
Neurological History (other than AD) None None None None None Restless legs Insomnia, headaches
Genitourinary History Urinary Tract Infection, prostatitis None None None None None Overactive bladder, prostate hypertrophy
Abnormal Posture Absent Absent Absent Absent Absent Absent Absent
Markedly Enlarged Ventricles? No No No No No No No
Other Lesions on Brain Scan None Non-specific deep white matter changes Small amt periventricular white matter changes None Mild changes noted on Flair image None None
Gait Normal Normal Normal Normal Normal Normal Poor balance, unable to tandem gait, slow gait, no arm swinging
MDRS 111 123 127 120 120 118 109
MMSE 19 25 26 25 21 20 26
Opening pressure 240 235 260 260 250 220 280