Figure 9From: The circumventricular organs participate in the immunopathogenesis of experimental autoimmune encephalomyelitisLocalization of inflammatory cell infiltrates in the brain of mice suffering from EAE are enriched in close vicinity to CVOs. During EAE, CD45+ cellular infiltrates in the brain were found to be enriched in close vicinity to CVOs. The top panel shows the SFO with perivascular CD45+ cells present within the CVO. Massive CD45+ infiltrates are prominent within the ventricular walls and the brain parenchyma outside but in close vicinity to SFO. The bottom panel shows the AP with perivascular and parenchymal CD45+ cells present within this CVO. Many CD45+ cells have accumulated at the border between the AP and the 4th ventricle. These pictures are representative for the finding that CD45+ inflammatory cell infiltrates in the brain were found to be enriched in number and size in close vicinity to CVOs during EAE. Immunoperoxidase, hematoxylin counterstain. Bar = 100 μm. This result was observed in at least 10 individual stainings.Back to article page