Figure 4From: Cerebrospinal fluid may mediate CNS ischemic injuryOverview of mechanisms underlying the CNS vulnerability to ischemia. Blood brain barrier and Blood-CSF barrier determine the low protein concentration in the cerebrospinal fluid and the interstitial fluid. A large amount of free fluid causes the CNS cells to consume more energy to maintain normal intracellular environment. The positive intracranial pressure facilitates the edema formation. Edema results in 'no-reflow' phenomenon.Back to article page