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  • Oral Presentation
  • Open Access

Neuropsychological profile of patients with normal pressure hydrocephalus and Alzheimer's disease

Cerebrospinal Fluid Research20041 (Suppl 1) :S17

  • Published:


  • Cognitive Impairment
  • Early Diagnosis
  • Late Stage
  • Neurological Disorder
  • Hydrocephalus

Normal pressure hydrocephalus (NPH) is a potentially treatable neurological disorder if diagnosed accurately and early. If misdiagnosed, or left untreated, the pattern is one of continuing physical and cognitive decline, which becomes increasingly irreversible as more diffuse brain damage is caused. Cognitive profiling is a technique, which can aid early and accurate detection of NPH.

This paper presents the results of two studies showing specific contrasting patterns of neuropsychological dysfunction in subgroups of patients with either early or late stage NPH with patients either in the prodromal stages (mild cognitive impairment) or later stages of Alzheimer's disease. The results demonstrate that there are differential patterns that can be observed in patients with NPH, which can be used effectively within a clinic-context to enhance accurate and early diagnosis and improve long-term prognosis.

Authors’ Affiliations

Department of Academic Neurosurgery, Addenbrooke's Hospital, Cambridge, UK


  1. Iddon JL, Pickard JD, et al: Specific patterns of cognitive impairment in patients with idiopathic normal pressure hydrocephalus and Alzheimer's disease. JNNP. 1999, 67: 723-732.Google Scholar
  2. Iddon JL: Cognitive dysfunction in hydrocephalus. In: Cognitive Deficits in Brain Disorders. Edited by: Harrison J, Owen AM. 2001, Martin Dunitz PublishersGoogle Scholar


© The Author(s) 2004

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.