Robert Thorne, Editorial Board Member
Denali Therapeutics & University of Minnesota, USA
Find publications in PubMed
Dr Robert G. Thorne is currently a full-time Denali Fellow at Denali Therapeutics (South San Francisco, California, USA) and an Adjunct Associate Professor in the Department of Pharmaceutics at the University of Minnesota (Minneapolis). He was previously a faculty member for over 10 years at the New York University School of Medicine (Department of Physiology and Neuroscience) and, most recently, at the University of Wisconsin-Madison where he was an Assistant Professor in Pharmaceutical Sciences and the Institute for Clinical and Translational Research, as well as a Trainer in the Neuroscience, Cellular and Molecular Pathology, and Clinical Neuroengineering Training Programs. The main focus of Dr. Thorne’s research has been the study of diffusive and convective transport within the extracellular and perivascular spaces of the central nervous system (CNS) and general concepts associated with CNS drug delivery and biodistribution – his group’s work has aimed to leverage knowledge of physiology, CNS structure, and the blood-brain and blood-cerebrospinal fluid barriers with a variety of methods in order to identify how best to deliver antibodies, oligonucleotides, and gene therapy vectors to the brain following intraparenchymal, intrathecal, or intranasal administration. His focus at Denali Therapeutics has broadened significantly to encompass all potential strategies for large molecule delivery to the brain, including brain endothelial cell receptor-targeted approaches for crossing the blood-brain barrier after systemic administration. Prof. Thorne has taught systems neuroscience, drug delivery, pharmacokinetics, research ethics, and science communication at the undergraduate, graduate and professional student level at multiple institutions, including the University of Washington, New York University School of Medicine, University of Wisconsin-Madison, University of Minnesota and Stanford University. Dr. Thorne previously chaired the 2016 ‘Barriers of the CNS’ Gordon Research Conference (https://www.grc.org/barriers-of-the-cns-conference/2016/) and co-edited the 2014 book ‘Drug Delivery to the Brain: Physiological Concepts, Methodologies and Approaches’ with Margareta Hammarlund-Udenaes and Elizabeth de Lange (https://link.springer.com/book/10.1007/978-1-4614-9105-7). He also co-chaired the inaugural joint AAPS-IBBS Workshop on ‘Novel Approaches Targeting Brain Barriers for Effective Delivery of Therapeutics’ in 2019. Finally, Dr. Thorne is currently a member of the editorial boards of both Fluids and Barriers of the CNS and the Journal of Cerebral Blood Flow and Metabolism and was elected in 2017 to serve as the Vice President (President-elect) of the International Brain Barriers Society, a global organization responsible for leadership and directing worldwide initiatives related to the CNS barriers and drug delivery fields.