Irena Loryan, MD, PhD, Uppsala University, Sweden
Editorial Board Member
Dr. Irena Loryan is researcher in the translational pharmacokinetics-pharmacodynamics (tPKPD) group in the Department of Pharmacy, Uppsala University, Sweden. She received her M.D. in 2001 and Ph.D. in pharmacology and biochemistry in 2007 from Yerevan State Medical University, Armenia. She then worked as a post-doctoral fellow at the Division of Pharmacogenetics at the Department of Pharmacology and Physiology, Karolinska Institute (Prof. Magnus Ingelman-Sundberg Lab). Since 2011, she worked as a post-doctoral fellow at the Department of Pharmaceutical Biosciences, Uppsala University (Prof. Margareta Hammarlund-Udenaes Lab) in collaboration with Janssen Pharmaceutica, Beerse, Belgium. Her current research interest focuses on neuropharmacokinetics of small and large molecular weight drugs, implying mechanistic understanding of drug disposition in central and peripheral nervous systems involving passage across CNS and PNS barriers, distribution within parenchyma and elimination processes in health and disease, with focus on neurodegenerative diseases. Specific emphasis is on investigation of PKPD relationship in discrete brain regions and development of new methods to study it. Investigation of translational aspects of neuropharmacokinetics from in vitro models to preclinical species and eventually to patients to support CNS drug discovery is the ultimate goal of the studies.