%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
2018-10-16T06:28:56+05:30
Springer
2018-10-19T12:18:55+02:00
2018-10-19T12:18:55+02:00
Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (AGPL-version)
ABC transporters,Amino acid metabolism,Basement membrane,Blood–brain barrier permeability,Branched chain amino acid shuttle,Carrier mechanism,Diffusion,Efflux rate constant,Linear free energy relations,Perivascular convection,SLC transporters,Transcytosis,Trans-stimulation,Volume of distribution
application/pdf
https://doi.org/10.1186/s12987-018-0113-6
BioMed Central
Fluids and Barriers of the CNS, https://doi.org/10.1186/s12987-018-0113-6
ABC transporters
Amino acid metabolism
Basement membrane
Blood–brain barrier permeability
Branched chain amino acid shuttle
Carrier mechanism
Diffusion
Efflux rate constant
Linear free energy relations
Perivascular convection
SLC transporters
Transcytosis
Trans-stimulation
Volume of distribution
Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier
Stephen B. Hladky
Margery A. Barrand
10.1186/s12987-018-0113-6
2010-04-23
true
springer.com
springerlink.com
https://doi.org/10.1186/s12987-018-0113-6
10.1186/s12987-018-0113-6
2045-8118
journal
Fluids and Barriers of the CNS
The Author(s)
2010-04-23
true
10.1186/s12987-018-0113-6
noindex
springer.com
springerlink.com
CVoR
uuid:e4b4285f-91b8-4d13-9e50-2bf1af126101
uuid:f222ce4a-1c81-45ab-bc03-56c5afbe363c
default
1
converted
uuid:88af2ff2-fc74-408c-ab78-1edc448a21df
converted to PDF/A-2b
pdfToolbox
2018-10-16T06:29:31+05:30
2
B
http://ns.adobe.com/pdfx/1.3/
pdfx
Adobe Document Info PDF eXtension Schema
external
Mirrors crossmark:MajorVersionDate
CrossmarkMajorVersionDate
Text
external
Mirrors crossmark:CrossmarkDomainExclusive
CrossmarkDomainExclusive
Text
internal
Mirrors crossmark:DOI
doi
Text
external
Mirrors crossmark:CrosMarkDomains
CrossMarkDomains
seq Text
internal
A name object indicating whether the document has been modified to include trapping information
robots
Text
internal
ID of PDF/X standard
GTS_PDFXVersion
Text
internal
Conformance level of PDF/X standard
GTS_PDFXConformance
Text
internal
Company creating the PDF
Company
Text
internal
Date when document was last modified
SourceModified
Text
http://crossref.org/crossmark/1.0/
crossmark
Crossmark Schema
internal
Usual same as prism:doi
DOI
Text
external
The date when a publication was publishe.
MajorVersionDate
Text
internal
CrossmarkDomainExclusive
CrossmarkDomainExclusive
Text
internal
CrossMarkDomains
CrossMarkDomains
seq Text
http://prismstandard.org/namespaces/basic/2.0/
prism
Prism Schema
external
This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.
url
URI
external
The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL).
doi
Text
external
ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.
issn
Text
internal
Volume number
volume
Text
internal
Issue number
number
Text
internal
Starting page
startingPage
Text
internal
Ending page
endingPage
Text
external
The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary.
aggregationType
Text
external
Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”
publicationName
Text
external
Copyright
copyright
Text
http://ns.adobe.com/pdf/1.3/
pdf
Adobe PDF Schema
internal
A name object indicating whether the document has been modified to include trapping information
Trapped
Text
http://ns.adobe.com/xap/1.0/mm/
xmpMM
XMP Media Management Schema
internal
UUID based identifier for specific incarnation of a document
InstanceID
URI
internal
The common identifier for all versions and renditions of a document.
DocumentID
URI
internal
The common identifier for all versions and renditions of a document.
OriginalDocumentID
URI
http://www.aiim.org/pdfa/ns/id/
pdfaid
PDF/A ID Schema
internal
Part of PDF/A standard
part
Integer
internal
Amendment of PDF/A standard
amd
Text
internal
Conformance level of PDF/A standard
conformance
Text
http://www.niso.org/schemas/jav/1.0/
jav
NISO
external
Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record
journal_article_version
Closed Choice of Text
endstream
endobj
3 0 obj
<>
endobj
8 0 obj
[9 0 R 10 0 R 11 0 R 12 0 R 13 0 R 14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R 69 0 R 70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R 77 0 R 78 0 R 79 0 R 80 0 R 81 0 R 82 0 R 83 0 R]
endobj
9 0 obj
<>/Rect[487.987 108.798 493.103 96.6309]/H/N/AP<>>>
endobj
10 0 obj
<>/Rect[56.6929 704.391 165.598 692.224]/H/N/AP<>>>
endobj
11 0 obj
<>/Rect[66.6929 690.241 290.551 678.074]/H/N/AP<>>>
endobj
12 0 obj
<>/Rect[83.6664 676.091 135.585 663.924]/H/N/AP<>>>
endobj
13 0 obj
<>/Rect[66.6929 661.941 245.646 649.774]/H/N/AP<>>>
endobj
14 0 obj
<>/Rect[84.6929 647.791 206.514 635.624]/H/N/AP<>>>
endobj
15 0 obj
<>/Rect[84.6929 633.641 290.551 621.474]/H/N/AP<>>>
endobj
16 0 obj
<>/Rect[108.82 619.491 159.162 607.324]/H/N/AP<>>>
endobj
17 0 obj
<>/Rect[66.6929 605.341 170.658 593.174]/H/N/AP<>>>
endobj
18 0 obj
<>/Rect[56.6929 591.191 197.123 579.024]/H/N/AP<>>>
endobj
19 0 obj
<>/Rect[66.6929 577.041 108.764 564.874]/H/N/AP<>>>
endobj
20 0 obj
<>/Rect[66.6929 562.891 146.953 550.724]/H/N/AP<>>>
endobj
21 0 obj
<>/Rect[66.6929 548.741 116.711 536.574]/H/N/AP<>>>
endobj
22 0 obj
<>/Rect[84.6929 534.591 290.551 522.424]/H/N/AP<>>>
endobj
23 0 obj
<>/Rect[108.82 520.441 290.551 508.274]/H/N/AP<>>>
endobj
24 0 obj
<>/Rect[108.82 506.291 217.587 494.124]/H/N/AP<>>>
endobj
25 0 obj
<>/Rect[84.6929 492.141 290.551 479.974]/H/N/AP<>>>
endobj
26 0 obj
<>/Rect[108.82 477.991 160.739 465.824]/H/N/AP<>>>
endobj
27 0 obj
<>/Rect[66.6929 463.841 113.683 451.674]/H/N/AP<>>>
endobj
28 0 obj
<>/Rect[66.6929 449.691 135.095 437.524]/H/N/AP<>>>
endobj
29 0 obj
<>/Rect[84.6929 435.541 290.551 423.374]/H/N/AP<>>>
endobj
30 0 obj
<>/Rect[108.82 421.391 136.188 405.667]/H/N/AP<>>>
endobj
31 0 obj
<>/Rect[84.6929 407.241 290.551 395.074]/H/N/AP<>>>
endobj
32 0 obj
<>/Rect[108.82 393.091 139.866 380.924]/H/N/AP<>>>
endobj
33 0 obj
<>/Rect[84.6929 378.941 290.551 366.774]/H/N/AP<>>>
endobj
34 0 obj
<>/Rect[108.82 364.791 290.551 352.624]/H/N/AP<>>>
endobj
35 0 obj
<>/Rect[108.82 350.641 132.752 338.474]/H/N/AP<>>>
endobj
36 0 obj
<>/Rect[84.6929 336.491 236.344 324.324]/H/N/AP<>>>
endobj
37 0 obj
<>/Rect[84.6929 322.341 290.551 310.174]/H/N/AP<>>>
endobj
38 0 obj
<>/Rect[108.82 308.191 290.551 296.024]/H/N/AP<>>>
endobj
39 0 obj
<>/Rect[108.82 294.041 168.599 281.874]/H/N/AP<>>>
endobj
40 0 obj
<>/Rect[84.6929 279.891 290.551 267.724]/H/N/AP<>>>
endobj
41 0 obj
<>/Rect[108.82 265.741 136.985 253.574]/H/N/AP<>>>
endobj
42 0 obj
<>/Rect[66.6929 251.591 135.419 235.867]/H/N/AP<>>>
endobj
43 0 obj
<>/Rect[66.6929 237.441 127.619 225.274]/H/N/AP<>>>
endobj
44 0 obj
<>/Rect[84.6929 223.291 212.718 211.124]/H/N/AP<>>>
endobj
45 0 obj
<>/Rect[107.693 209.141 290.551 196.974]/H/N/AP<>>>
endobj
46 0 obj
<>/Rect[107.693 194.991 241.988 182.824]/H/N/AP<>>>
endobj
47 0 obj
<>/Rect[107.693 180.841 290.551 168.674]/H/N/AP<>>>
endobj
48 0 obj
<>/Rect[107.693 166.691 199.8 154.524]/H/N/AP<>>>
endobj
49 0 obj
<>/Rect[84.6929 152.541 290.551 140.374]/H/N/AP<>>>
endobj
50 0 obj
<>/Rect[108.82 138.391 290.551 126.224]/H/N/AP<>>>
endobj
51 0 obj
<>/Rect[108.82 124.241 249.927 112.074]/H/N/AP<>>>
endobj
52 0 obj
<>/Rect[84.6929 110.091 290.551 97.9239]/H/N/AP<>>>
endobj
53 0 obj
<>/Rect[108.82 95.9406 200.948 83.7739]/H/N/AP<>>>
endobj
54 0 obj
<>/Rect[304.724 704.391 471.439 692.224]/H/N/AP<>>>
endobj
55 0 obj
<>/Rect[314.724 690.241 538.583 678.074]/H/N/AP<>>>
endobj
56 0 obj
<>/Rect[331.698 676.091 524.819 663.924]/H/N/AP<>>>
endobj
57 0 obj
<>/Rect[314.724 661.941 507.849 649.774]/H/N/AP<>>>
endobj
58 0 obj
<>/Rect[304.724 647.791 354.322 635.624]/H/N/AP<>>>
endobj
59 0 obj
<>/Rect[304.724 633.641 361.23 621.474]/H/N/AP<>>>
endobj
60 0 obj
<>/Rect[304.724 619.491 456.63 607.324]/H/N/AP<>>>
endobj
61 0 obj
<>/Rect[314.724 605.341 389.203 593.174]/H/N/AP<>>>
endobj
62 0 obj
<>/Rect[314.724 591.191 366.252 579.024]/H/N/AP<>>>
endobj
63 0 obj
<>/Rect[314.724 577.041 538.583 564.874]/H/N/AP<>>>
endobj
64 0 obj
<>/Rect[331.698 562.891 368.739 550.724]/H/N/AP<>>>
endobj
65 0 obj
<>/Rect[314.724 548.741 464.318 536.574]/H/N/AP<>>>
endobj
66 0 obj
<>/Rect[304.724 534.591 362.974 522.424]/H/N/AP<>>>
endobj
67 0 obj
<>/Rect[304.724 520.441 538.583 508.274]/H/N/AP<>>>
endobj
68 0 obj
<>/Rect[304.724 506.291 435.356 494.124]/H/N/AP<>>>
endobj
69 0 obj
<>/Rect[314.724 492.141 538.583 479.974]/H/N/AP<>>>
endobj
70 0 obj
<>/Rect[314.724 477.991 469.668 465.824]/H/N/AP<>>>
endobj
71 0 obj
<>/Rect[314.724 463.841 538.583 451.674]/H/N/AP<>>>
endobj
72 0 obj
<>/Rect[314.724 449.691 345.839 437.524]/H/N/AP<>>>
endobj
73 0 obj
<>/Rect[304.724 435.541 538.583 423.374]/H/N/AP<>>>
endobj
74 0 obj
<>/Rect[304.724 421.391 538.583 409.224]/H/N/AP<>>>
endobj
75 0 obj
<>/Rect[304.724 407.241 417.882 395.074]/H/N/AP<>>>
endobj
76 0 obj
<>/Rect[304.724 393.091 538.583 380.924]/H/N/AP<>>>
endobj
77 0 obj
<>/Rect[304.724 378.941 538.583 366.774]/H/N/AP<>>>
endobj
78 0 obj
<>/Rect[304.724 364.791 387.826 352.624]/H/N/AP<>>>
endobj
79 0 obj
<>/Rect[304.724 350.641 538.583 338.474]/H/N/AP<>>>
endobj
80 0 obj
<>/Rect[304.724 336.491 429.22 324.324]/H/N/AP<>>>
endobj
81 0 obj
<>/Rect[304.724 322.341 538.583 306.617]/H/N/AP<>>>
endobj
82 0 obj
<>/Rect[304.724 308.191 351.195 292.467]/H/N/AP<>>>
endobj
83 0 obj
<>/Rect[304.724 294.041 348.863 281.874]/H/N/AP<>>>
endobj
6 0 obj
<>/XObject<>/ProcSet[/PDF/Text]/Font<>>>
endobj
5 0 obj
<>stream
x[Y6 G#hZ}0aǒXA
%1psHE;UMy̮H;!ꫪ`1cn^?y'Wļ&T3qMb)㑊S
X^?"
9d2⯳֔'_5مQ&'[xmގ}8Wpɖ_EW!Le/6A!yr3/6aWUn /Gys*P PQw܀8[nI`EmYI^
E&"x
\( *T9704!OK9 VDHs]8@Dxw
@1!i⟈'%{=vƴKryC.9kMg|ml]Ĕhhm^"9KG;/(s
J ܺR$0`*o>Wܜ)aOT=$oj("F{Mg&wviԲiUaM<t|>/N~ |O{> /V3#rߑ,%5葭r+
y~ԻMVA(x!X卹/Asg'D?夨
^lo?7!6)ZyKX&%aﭼrvIw@yߵEaRPIdNN~ċyb3(KLڙߘ̫:V9uGڗXj0p(+]谂W,Ŀ[qhA8#+,F.muX VM̭r-wk!uA-/ jdPMAx5(A%tb>jz㧲&Ȳp$o|MssAZ+2"y@8_ ˠ<
G@q>s; -)oks;u
rY¡d(XҠO6(-k[}1&T