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Table 1 RMT targeting antibodies used in the mBEC and iBEC BBB transcytosis assays.

From: Mouse embryonic stem cell-derived blood–brain barrier model: applicability to studying antibody triggered receptor mediated transcytosis

Antibody

Type

Receptor

Affinitya

Species-cross-reactivity

FC5-Fc

VHH-Fc (80 kD)

TMEM30A

50 nM (L-M)

Mouse-rat-human-dog-NHP

J05-Fc

VHH-Fc (80 kD)

TfR

300 nM (L)

Mouse-rat-human

8D3

IgG (150 kD)

TfR

1.2 nM (H)

Mouse

8D3v2

IgG (150 kD)

TfR

130 nM (L)

Mouse

IGF1R5-FC

VHH-Fc (80 kD)

IGF1R

1 nM (H)

Mouse-rat-human

A20.1

VHH (13 kD)

C. Diff Toxin A

2 nM (H)

No mammalian target

  1. aL Low, M Moderate, H High Affinity