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Fig. 8 | Fluids and Barriers of the CNS

Fig. 8

From: Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody

Fig. 8

a Ex vivo autoradiography of representative brain sections (NB not corrected for injected dose or weight of animal) b Quantification of brain section radioactivity of the whole brain area (ROI). Pairwise comparisons between young and aged mice of each genotype were done using one-way analysis of variance, with Bonferroni correction c Correlation between radioactivity (Bq) and brain concentration (%ID/g brain), statistical analysis by Pearson's correlation test (low dose: r = 0.57*, p = 0.01, high dose: r = 0.88****, p < 0.0001). Significant p-value is defined as p < 0.05, *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001)

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