Fig. 5
From: Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody
a–l Brain concentration (%ID/g brain), %ID/g/bw and brain-to-plasma ratios for WT and tg-ArcSwe mice, administered bispecific [125I]mAb3D6-scfv8D3 at high and low dose. To test significance in the results between young and aged mice, unpaired t-tests were used for brain concentrations; %ID/gBrain or %ID/g(bw)Brain and Mann–Whitney U-tests were used for brain-to-plasma ratios, due to non-normality. Significant p-value is defined as p < 0.05, *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001)