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Fig. 4 | Fluids and Barriers of the CNS

Fig. 4

From: Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody

Fig. 4

Percentage distribution to the plasma (%Plasma) vs blood cell fraction of [125I]mAb3D6-scFv8D3 in a WT and b tg-ArcSwe mice. Significant differences between low and high doses of [125I]mAb3D6-scFv8D3, as analysed with Kruskal–Wallis followed by Dunn's post-hoc analysis for multiple comparisons c-d Percentage in plasma and blood cell fractions over time after in vitro spiking with [125I]mAb3D6-scFv8D3 in blood from young and aged mice, at high and low dosing. AUCplasma was significantly higher in the blood from young mice, compared with aged, at high dosing (p = 0.04), but did not reach statistical significance for low dose (p = 0.07) when analysed by pairwise one-way analysis of variance with Bonferroni correction. Significant p-value is defined as p < 0.05, *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001)

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