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Fig. 4 | Fluids and Barriers of the CNS

Fig. 4

From: Inhibition of lysophosphatidic acid receptor 1 relieves PMN recruitment in CNS via LPA1/TSP1/CXCR2 pathway and alleviates disruption on blood-brain barrier following intracerebral haemorrhage in mice

Fig. 4

Representative images of Evans Blue staining (A); Evans Blue Extravasation analyses (B); Representative images of immunofluorescence staining of CD31 (red) and ZO-1 (green) in the perihematomal region (C) and Quantitative analyses of CD31/ ZO-1 positive cells in the perihematomal region (D) at 24 h post-ICH. The effects of AM966 on brain water content (E); modified Garcia score (F); Limb Placement score (G) and Corner Turn score (H); One-way ANOVA, Tukey’s test, mean ± SD (error bars), (B; D; F-H) and two-way repeated measures ANOVA, Tukey’s test, mean ± SD (error bars) (E), n = 6 per group. *p < 0.05 vs. sham group; #p < 0.05 vs. ICH + Vehicle group. Ipsi-BG ipsilateral basal ganglia, Ipsi-CX ipsilateral cortex, Cont-BG contralateral basal ganglia, Cont-CX contralateral cortex, Cerebel cerebellum

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Fluids and Barriers of the CNS

ISSN: 2045-8118