Fig. 5

LRP1 expression in neurons and capillaries in hippocampal subfields and frontal cortex following 4 weeks of lose-dose in vivo Pb exposure. A IHC staining of hippocampal CA1 region with LRP1 and CD31. LRP1 expression in CA1 neurons (A′ and A‴) and capillaries (A″ and A⁗) were further magnified in panels below. B Quantification of LRP1 expression by fluorescent intensity in neurons and capillaries in hippocampal CA1 region. C IHC staining of hippocampal CA3 region with LRP1 and CD31. LRP1 expression in CA3 neurons (C′ and C‴) and capillaries (C″ and C⁗) were further magnified in panels below. D Quantification of LRP1 fluorescent intensity in neurons and capillaries in hippocampal CA3 region. E IHC staining of hippocampal dentate gyrus (DG) with LRP1 and CD31. LRP1 expression in DG neurons (E′ and E‴) and capillaries (E″ and E⁗) were further magnified in panels below. F Quantification of LRP1 expression by fluorescent intensity in neurons and capillaries in hippocampal DG. G IHC staining of frontal cortex region with LRP1 and CD31. Pial surface (Pial.) and corpus callosum (CC) were labeled to show LRP1 expression pattern. Selected regions were further magnified to show LRP1 expression in cortical neurons and capillaries as affected by Pb exposure. H Quantification of LRP1 expression by immunofluorescent intensity in neurons and capillaries in frontal cortex. Data represent mean ± SD, n = 4; **p < 0.01, as compared to the controls in the specific fraction